Functional α6β4 acetylcholine receptor expression enables pharmacological testing of nicotinic agonists with analgesic properties

The α6β4 nicotinic acetylcholine receptor (nAChR) is enriched in dorsal root ganglia neurons and is an attractive non-opioid therapeutic target for pain. However, difficulty expressing human α6β4 receptors in recombinant systems has precluded drug discovery. Here, genome-wide screening identified ac...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Knowland, Daniel, Gu, Shenyan, Eckert, William A., Dawe, G. Brent, Matta, Jose A., Limberis, James, Wickenden, Alan D., Bhattacharya, Anindya, Bredt, David S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598046/
https://ncbi.nlm.nih.gov/pubmed/33074244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140311
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