Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how complement interacts with the platelet/neutrophil extr...

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Vydáno v:J Clin Invest
Hlavní autoři: Skendros, Panagiotis, Mitsios, Alexandros, Chrysanthopoulou, Akrivi, Mastellos, Dimitrios C., Metallidis, Simeon, Rafailidis, Petros, Ntinopoulou, Maria, Sertaridou, Eleni, Tsironidou, Victoria, Tsigalou, Christina, Tektonidou, Maria, Konstantinidis, Theocharis, Papagoras, Charalampos, Mitroulis, Ioannis, Germanidis, Georgios, Lambris, John D., Ritis, Konstantinos
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Concise Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7598040/
https://ncbi.nlm.nih.gov/pubmed/32759504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141374
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