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Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

BACKGROUND: Gout is a prevalent inflammatory arthritis affecting 1–2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their...

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Detalhes bibliográficos
Main Authors: Mitroulis, Ioannis, Kambas, Konstantinos, Chrysanthopoulou, Akrivi, Skendros, Panagiotis, Apostolidou, Eirini, Kourtzelis, Ioannis, Drosos, Georgios I., Boumpas, Dimitrios T., Ritis, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241704/
https://ncbi.nlm.nih.gov/pubmed/22195044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029318
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