IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

INTRODUCTION: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts (SF) as a direct cellular target to IL6/sIL6R signal is not well characterized. The purpos...

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Publicat a:BMC Mol Cell Biol
Autors principals: Valin, Alvaro, Del Rey, Manuel J., Municio, Cristina, Usategui, Alicia, Romero, Marina, Fernández-Felipe, Jesús, Cañete, Juan D., Blanco, Francisco J., Ruano, Yolanda, Criado, Gabriel, Pablos, José L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596982/
https://ncbi.nlm.nih.gov/pubmed/33126846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12860-020-00317-7
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