Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O(2) environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribution of...

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Publicado en:Sci Rep
Autores principales: Del Rey, Manuel J., Valín, Álvaro, Usategui, Alicia, García-Herrero, Carmen M., Sánchez-Aragó, María, Cuezva, José M., Galindo, María, Bravo, Beatriz, Cañete, Juan D., Blanco, Francisco J., Criado, Gabriel, Pablos, José L.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473902/
https://ncbi.nlm.nih.gov/pubmed/28623342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03921-4
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