Hif-1α Knockdown Reduces Glycolytic Metabolism and Induces Cell Death of Human Synovial Fibroblasts Under Normoxic Conditions

Increased glycolysis and HIF-1α activity are characteristics of cells under hypoxic or inflammatory conditions. Besides, in normal O(2) environments, elevated rates of glycolysis support critical cellular mechanisms such as cell survival. The purpose of this study was to analyze the contribution of...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Del Rey, Manuel J., Valín, Álvaro, Usategui, Alicia, García-Herrero, Carmen M., Sánchez-Aragó, María, Cuezva, José M., Galindo, María, Bravo, Beatriz, Cañete, Juan D., Blanco, Francisco J., Criado, Gabriel, Pablos, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473902/
https://ncbi.nlm.nih.gov/pubmed/28623342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03921-4
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