Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases

BACKGROUND: Ocular neovascularization is a hallmark of retinal diseases including neovascular age-related macular degeneration and diabetic retinopathy, two leading causes of blindness in adults. Neovascularization is driven by the interaction of soluble vascular endothelial growth factor (VEGF) lig...

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Bibliografiske detaljer
Udgivet i:Cell Mol Bioeng
Main Authors: Kureshi, Rakeeb, Zhu, Angela, Shen, Jikui, Tzeng, Stephany Y., Astrab, Leilani R., Sargunas, Paul R., Green, Jordan J., Campochiaro, Peter A., Spangler, Jamie B.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
Fag:
2020 CMBE Young Innovators issue
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596137/
https://ncbi.nlm.nih.gov/pubmed/33184574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12195-020-00641-0
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