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Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer

Novel effective treatment is direly needed for patients with pancreatic ductal adenocarcinoma (PDAC). Therapeutics that target the driver mutations, especially the KRAS oncoprotein and its effector cascades, have been ineffective. It is increasing clear that the extensive fibro-inflammatory stroma (...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Bulle, Ashenafi, Lim, Kian-Huat
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7596088/
https://ncbi.nlm.nih.gov/pubmed/33122631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00341-1
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