TET family regulates the embryonic pluripotency of porcine preimplantation embryos by maintaining the DNA methylation level of NANOG

The ten-eleven translocation (TET) family (TET1/2/3) initiates conversion of 5-methylcytosine to 5-hydroxymethylcytosine, thereby orchestrating the DNA demethylation process and changes in epigenetic marks during early embryogenesis. In this study, CRISPR/Cas9 technology and a TET-specific inhibitor...

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發表在:Epigenetics
Main Authors: Uh, Kyungjun, Ryu, Junghyun, Farrell, Kayla, Wax, Noah, Lee, Kiho
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2020
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Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595583/
https://ncbi.nlm.nih.gov/pubmed/32397801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1762392
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