Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells

In the search of small molecules that can target MDM2/p53 pathway in testicular germ cell tumors (TGCTs), we identified sempervirine (2,3,4,13-tetrahydro-1H-benz[g]indolo[2,3-a]quinolizin-6-ium), an alkaloid of Gelsemium sempervirens, that has been previously proposed as an inhibitor of MDM2 that ta...

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Bibliografiske detaljer
Udgivet i:Cell Death Discov
Main Authors: Caggiano, Cinzia, Guida, Eugenia, Todaro, Federica, Bielli, Pamela, Mori, Mattia, Ghirga, Francesca, Quaglio, Deborah, Botta, Bruno, Moretti, Fabiola, Grimaldi, Paola, Rossi, Pellegrino, Jannini, Emmanuele A., Barchi, Marco, Dolci, Susanna
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595235/
https://ncbi.nlm.nih.gov/pubmed/33298840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00345-4
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