ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs

The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angioten...

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Publicat a:Nat Commun
Autors principals: Lee, Ivan T., Nakayama, Tsuguhisa, Wu, Chien-Ting, Goltsev, Yury, Jiang, Sizun, Gall, Phillip A., Liao, Chun-Kang, Shih, Liang-Chun, Schürch, Christian M., McIlwain, David R., Chu, Pauline, Borchard, Nicole A., Zarabanda, David, Dholakia, Sachi S., Yang, Angela, Kim, Dayoung, Chen, Han, Kanie, Tomoharu, Lin, Chia-Der, Tsai, Ming-Hsui, Phillips, Katie M., Kim, Raymond, Overdevest, Jonathan B., Tyler, Matthew A., Yan, Carol H., Lin, Chih-Feng, Lin, Yi-Tsen, Bau, Da-Tian, Tsay, Gregory J., Patel, Zara M., Tsou, Yung-An, Tzankov, Alexandar, Matter, Matthias S., Tai, Chih-Jaan, Yeh, Te-Huei, Hwang, Peter H., Nolan, Garry P., Nayak, Jayakar V., Jackson, Peter K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7595232/
https://ncbi.nlm.nih.gov/pubmed/33116139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19145-6
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