Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers

We investigated the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of healthy human donors. We detected ACE2 protein expression within the cilia organelle of ciliated airway...

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Detalhes bibliográficos
Publicado no:medRxiv
Main Authors: Lee, Ivan T., Nakayama, Tsuguhisa, Wu, Chien-Ting, Goltsev, Yury, Jiang, Sizun, Gall, Phillip A., Liao, Chun-Kang, Shih, Liang-Chun, Schürch, Christian M., McIlwain, David R., Chu, Pauline, Borchard, Nicole A., Zarabanda, David, Dholakia, Sachi S., Yang, Angela, Kim, Dayoung, Kanie, Tomoharu, Lin, Chia-Der, Tsai, Ming-Hsui, Phillips, Katie M., Kim, Raymond, Overdevest, Jonathan B., Tyler, Matthew A., Yan, Carol H., Lin, Chih-Feng, Lin, Yi-Tsen, Bau, Da-Tian, Tsay, Gregory J., Patel, Zara M., Tsou, Yung-An, Tai, Chih-Jaan, Yeh, Te-Huei, Hwang, Peter H., Nolan, Garry P., Nayak, Jayakar V., Jackson, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7273284/
https://ncbi.nlm.nih.gov/pubmed/32511516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.05.08.20092866
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