Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma

BACKGROUND: O(6)-methylguanine DNA-methyl transferase (MGMT) promoter methylation status is predictive for alkylating chemotherapy, but there are non-benefiting subgroups. METHODS: This is the long-term update of NOA-08 (NCT01502241), which compared efficacy and safety of radiotherapy (RT, n = 176)...

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Vydáno v:Neuro Oncol
Hlavní autoři: Wick, Antje, Kessler, Tobias, Platten, Michael, Meisner, Christoph, Bamberg, Michael, Herrlinger, Ulrich, Felsberg, Jörg, Weyerbrock, Astrid, Papsdorf, Kirsten, Steinbach, Joachim P, Sabel, Michael, Vesper, Jan, Debus, Jürgen, Meixensberger, Jürgen, Ketter, Ralf, Hertler, Caroline, Mayer-Steinacker, Regine, Weisang, Sarah, Bölting, Hanna, Reuss, David, Reifenberger, Guido, Sahm, Felix, von Deimling, Andreas, Weller, Michael, Wick, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594575/
https://ncbi.nlm.nih.gov/pubmed/32064499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa033
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