Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. We hypothesized that non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could b...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Yao, Jingwen, Chakhoyan, Ararat, Nathanson, David A, Yong, William H, Salamon, Noriko, Raymond, Catalina, Mareninov, Sergey, Lai, Albert, Nghiemphu, Phioanh L, Prins, Robert M, Pope, Whitney B, Everson, Richard G, Liau, Linda M, Cloughesy, Timothy F, Ellingson, Benjamin M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
Neuro-Imaging
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594567/
https://ncbi.nlm.nih.gov/pubmed/31066901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz078
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