Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. We hypothesized that non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could b...

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Bibliografische gegevens
Gepubliceerd in:Neuro Oncol
Hoofdauteurs: Yao, Jingwen, Chakhoyan, Ararat, Nathanson, David A, Yong, William H, Salamon, Noriko, Raymond, Catalina, Mareninov, Sergey, Lai, Albert, Nghiemphu, Phioanh L, Prins, Robert M, Pope, Whitney B, Everson, Richard G, Liau, Linda M, Cloughesy, Timothy F, Ellingson, Benjamin M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Neuro-Imaging
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594567/
https://ncbi.nlm.nih.gov/pubmed/31066901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz078
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