Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. We hypothesized that non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could b...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Yao, Jingwen, Chakhoyan, Ararat, Nathanson, David A, Yong, William H, Salamon, Noriko, Raymond, Catalina, Mareninov, Sergey, Lai, Albert, Nghiemphu, Phioanh L, Prins, Robert M, Pope, Whitney B, Everson, Richard G, Liau, Linda M, Cloughesy, Timothy F, Ellingson, Benjamin M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Neuro-Imaging
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594567/
https://ncbi.nlm.nih.gov/pubmed/31066901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz078
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