Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. We hypothesized that non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could b...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Yao, Jingwen, Chakhoyan, Ararat, Nathanson, David A, Yong, William H, Salamon, Noriko, Raymond, Catalina, Mareninov, Sergey, Lai, Albert, Nghiemphu, Phioanh L, Prins, Robert M, Pope, Whitney B, Everson, Richard G, Liau, Linda M, Cloughesy, Timothy F, Ellingson, Benjamin M
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Neuro-Imaging
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594567/
https://ncbi.nlm.nih.gov/pubmed/31066901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz078
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