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Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI

BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutant gliomas are thought to have distinct metabolic characteristics, including a blunted response to hypoxia and lower glycolytic flux. We hypothesized that non-invasive quantification of abnormal metabolic behavior in human IDH1 mutant gliomas could b...

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Dades bibliogràfiques
Publicat a:Neuro Oncol
Autors principals: Yao, Jingwen, Chakhoyan, Ararat, Nathanson, David A, Yong, William H, Salamon, Noriko, Raymond, Catalina, Mareninov, Sergey, Lai, Albert, Nghiemphu, Phioanh L, Prins, Robert M, Pope, Whitney B, Everson, Richard G, Liau, Linda M, Cloughesy, Timothy F, Ellingson, Benjamin M
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594567/
https://ncbi.nlm.nih.gov/pubmed/31066901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz078
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