Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies

Colony-stimulating factor 3 receptor (CSF3R) encodes the receptor for granulocyte colony-stimulating factor (G-CSF), a cytokine vital for granulocyte proliferation and differentiation. Acquired activating heterozygous variants in CSF3R are the main cause of chronic neutrophilic leukemia, a hyperprol...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Trottier, Amy M., Druhan, Lawrence J., Kraft, Ira L., Lance, Amanda, Feurstein, Simone, Helgeson, Maria, Segal, Jeremy P., Das, Soma, Avalos, Belinda R., Godley, Lucy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594406/
https://ncbi.nlm.nih.gov/pubmed/33108454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002013
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