HIV-1 Nef Interacts with LMP7 To Attenuate Immunoproteasome Formation and Major Histocompatibility Complex Class I Antigen Presentation

The proteasome is a major protein degradation machinery with essential and diverse biological functions. Upon induction by cytokines, proteasome subunits β1, β2, and β5 are replaced by β1i/LMP2, β2i/MECL-1, and β5i/LMP7, resulting in the formation of an immunoproteasome (iProteasome). iProteasome-de...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Yang, Yang, Liu, Weiyong, Hu, Dan, Su, Rui, Ji, Man, Huang, Yuqing, Shereen, Muhammad Adnan, Xu, Xiaodi, Luo, Zhen, Zhang, Qi, Liu, Fang, Wu, Kailang, Liu, Yingle, Wu, Jianguo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593969/
https://ncbi.nlm.nih.gov/pubmed/33109760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02221-19
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