Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine

MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutations. Successful repair requires MutY recognition of the OG:A mispair amidst highly abundant and structurall...

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Publicado en:J Am Chem Soc
Autores principales: Lee, Andrea J., Majumdar, Chandrima, Kathe, Scott D., Van Ostrand, Robert P., Vickery, Holly R., Averill, April M., Nelson, Shane R., Manlove, Amelia H., McCord, Morgan A., David, Sheila S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593828/
https://ncbi.nlm.nih.gov/pubmed/32664726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c04284
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