Carregant...
Detection of OG:A lesion mispairs by MutY relies on interactions of a single His residue with the 2-amino group of 8-oxoguanine
MutY glycosylase excises adenines misincorporated opposite the oxidatively damaged lesion, 8-oxo-7,8-dihydroguanine (OG), to initiate base excision repair and prevent G to T transversion mutations. Successful repair requires MutY recognition of the OG:A mispair amidst highly abundant and structurall...
Guardat en:
| Publicat a: | J Am Chem Soc |
|---|---|
| Autors principals: | , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7593828/ https://ncbi.nlm.nih.gov/pubmed/32664726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c04284 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|