Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants

IMPORTANCE: Several clinical trials are planned for familial forms of frontotemporal lobar degeneration (f-FTLD). Precise modeling of brain atrophy in f-FTLD could improve the power to detect a treatment effect. OBJECTIVE: To characterize regions and rates of atrophy in the 3 primary f-FTLD genetic...

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Bibliografski detalji
Izdano u:JAMA Netw Open
Glavni autori: Staffaroni, Adam M., Goh, Sheng-Yang M., Cobigo, Yann, Ong, Elise, Lee, Suzee E., Casaletto, Kaitlin B., Wolf, Amy, Forsberg, Leah K., Ghoshal, Nupur, Graff-Radford, Neill R., Grossman, Murray, Heuer, Hilary W., Hsiung, Ging-Yuek R., Kantarci, Kejal, Knopman, David S., Kremers, Walter K., Mackenzie, Ian R., Miller, Bruce L., Pedraza, Otto, Rascovsky, Katya, Tartaglia, M. Carmela, Wszolek, Zbigniew K., Kramer, Joel H., Kornak, John, Boeve, Bradley F., Boxer, Adam L., Rosen, Howard J.
Format: Artigo
Jezik:Inglês
Izdano: American Medical Association 2020
Teme:
Original Investigation
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593814/
https://ncbi.nlm.nih.gov/pubmed/33112398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.22847
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