Rates of Brain Atrophy Across Disease Stages in Familial Frontotemporal Dementia Associated With MAPT, GRN, and C9orf72 Pathogenic Variants

IMPORTANCE: Several clinical trials are planned for familial forms of frontotemporal lobar degeneration (f-FTLD). Precise modeling of brain atrophy in f-FTLD could improve the power to detect a treatment effect. OBJECTIVE: To characterize regions and rates of atrophy in the 3 primary f-FTLD genetic...

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Publicat a:JAMA Netw Open
Autors principals: Staffaroni, Adam M., Goh, Sheng-Yang M., Cobigo, Yann, Ong, Elise, Lee, Suzee E., Casaletto, Kaitlin B., Wolf, Amy, Forsberg, Leah K., Ghoshal, Nupur, Graff-Radford, Neill R., Grossman, Murray, Heuer, Hilary W., Hsiung, Ging-Yuek R., Kantarci, Kejal, Knopman, David S., Kremers, Walter K., Mackenzie, Ian R., Miller, Bruce L., Pedraza, Otto, Rascovsky, Katya, Tartaglia, M. Carmela, Wszolek, Zbigniew K., Kramer, Joel H., Kornak, John, Boeve, Bradley F., Boxer, Adam L., Rosen, Howard J.
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2020
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593814/
https://ncbi.nlm.nih.gov/pubmed/33112398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2020.22847
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