Ustekinumab Inhibits T Follicular Helper Cell Differentiation in Patients With Crohn’s Disease

BACKGROUND & AIMS: The pathogenesis of chronic inflammatory bowel diseases (Crohn’s disease [CD] and ulcerative colitis) involves dysregulated TH1 and TH17 cell responses, which can be targeted therapeutically by the monoclonal antibody Ustekinumab directed against the joint p40 subunit of IL-12...

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Detalhes bibliográficos
Publicado no:Cell Mol Gastroenterol Hepatol
Main Authors: Globig, Anna-Maria, Sommer, Nikola Patricia, Wild, Katharina, Schardey, Josefine, Zoldan, Katharina, Thomann, Anne Kerstin, Schulte, Lucas-Alexander, Schreiner, Rupert, Reindl, Wolfgang, Klaus, Jochen, Schempp, Christoph Mathis, Hofmann, Maike, Thimme, Robert, Boettler, Tobias, Hasselblatt, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7593584/
https://ncbi.nlm.nih.gov/pubmed/32679193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.07.005
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