Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis

The Type I Interferons (IFN-Is) are innate antiviral cytokines that include 12 different IFNα subtypes and IFNβ that signal through the IFN-I receptor (IFNAR), inducing hundreds of IFN-stimulated genes (ISGs) that comprise the ‘interferome’. Quantitative differences in IFNAR binding correlate with a...

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Vydáno v:PLoS Pathog
Hlavní autoři: Guo, Kejun, Shen, Guannan, Kibbie, Jon, Gonzalez, Tania, Dillon, Stephanie M., Smith, Harry A., Cooper, Emily H., Lavender, Kerry, Hasenkrug, Kim J., Sutter, Kathrin, Dittmer, Ulf, Kroehl, Miranda, Kechris, Katerina, Wilson, Cara C., Santiago, Mario L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592919/
https://ncbi.nlm.nih.gov/pubmed/33064743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008986
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