Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothelial cells (RMECs) play an important r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Commun Signal
Päätekijät: Guo, Yue, Gu, Ruiping, Gan, Dekang, Hu, Fangyuan, Li, Gang, Xu, Gezhi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2020
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592595/
https://ncbi.nlm.nih.gov/pubmed/33115500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00637-3
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia