Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells

BACKGROUND: Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious inflammation. Retinal microvascular endothelial cells (RMECs) play an important r...

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Publicat a:Cell Commun Signal
Autors principals: Guo, Yue, Gu, Ruiping, Gan, Dekang, Hu, Fangyuan, Li, Gang, Xu, Gezhi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592595/
https://ncbi.nlm.nih.gov/pubmed/33115500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00637-3
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