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Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation

The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death. Missense activating mutations in NLRC4 cause autoinflammatory disorders whose symptoms are distinctly depende...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Sasaki, Yuki, Otsuka, Kunihiro, Arimochi, Hideki, Tsukumo, Shin-Ichi, Yasutomo, Koji
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7592392/
https://ncbi.nlm.nih.gov/pubmed/33178225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.591713
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