Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis

Interleukin (IL) 35 is a novel immunosuppressive heterodimeric cytokine in IL-12 family. Whether and how IL-35 regulates ischemia-induced angiogenesis in peripheral artery diseases are unrevealed. To fill this important knowledge gap, we used loss-of-function, gain-of-function, omics data analysis,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Fu, Hangfei, Sun, Yu, Shao, Ying, Saredy, Jason, Cueto, Ramon, Liu, Lu, Drummer, Charles, Johnson, Candice, Xu, Keman, Lu, Yifan, Li, Xinyuan, Meng, Shu, Xue, Eric R., Tan, Judy, Jhala, Nirag C., Yu, Daohai, Zhou, Yan, Bayless, Kayla J., Yu, Jun, Rogers, Thomas J., Hu, Wenhui, Snyder, Nathaniel W., Sun, Jianxin, Qin, Xuebin, Jiang, Xiaohua, Wang, Hong, Yang, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591706/
https://ncbi.nlm.nih.gov/pubmed/33154757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.595813
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