A qPCR Method for AAV Genome Titer with ddPCR-Level of Accuracy and Precision

Recombinant adeno-associated virus (rAAV) is one of the main vectors used in gene therapy. An accurate genome titer is not only critical for clinical dosing, but also a prerequisite for many analytical assays for AAV product characterization. AAV genome titer is traditionally determined by qPCR; how...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Methods Clin Dev
Prif Awduron: Wang, Yu, Menon, Namrata, Shen, Shen, Feschenko, Marina, Bergelson, Svetlana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Gene & Cell Therapy 2020
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591332/
https://ncbi.nlm.nih.gov/pubmed/33145370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.09.017
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