KSHV G-protein coupled receptor vGPCR oncogenic signaling upregulation of Cyclooxygenase-2 expression mediates angiogenesis and tumorigenesis in Kaposi’s sarcoma

Kaposi’s sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi’s sarcoma. Cyclooxygenase-2 (COX-2) is an inflammatory mediator that plays a key regulato...

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Publicado en:PLoS Pathog
Autores principales: Medina, María Victoria, D´Agostino, Agata, Ma, Qi, Eroles, Pilar, Cavallin, Lucas, Chiozzini, Chiara, Sapochnik, Daiana, Cymeryng, Cora, Hyjek, Elizabeth, Cesarman, Ethel, Naipauer, Julian, Mesri, Enrique A., Coso, Omar A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591070/
https://ncbi.nlm.nih.gov/pubmed/33057440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009006
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