A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli

Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-l...

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發表在:J Med Chem
Main Authors: Goldberg, Joel A., Nguyen, Ha, Kumar, Vijay, Spencer, Elizabeth J., Hoyer, Denton, Marshall, Emma K., Cmolik, Anna, O’Shea, Margaret, Marshall, Steven H., Hujer, Andrea M., Hujer, Kristine M., Rudin, Susan D., Domitrovic, T. Nicholas, Bethel, Christopher R., Papp-Wallace, Krisztina M., Logan, Latania K., Perez, Federico, Jacobs, Michael R., van Duin, David, Kreiswirth, Barry M., Bonomo, Robert A., Plummer, Mark S., van den Akker, Focco
格式: Artigo
語言:Inglês
出版: 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590959/
https://ncbi.nlm.nih.gov/pubmed/32420736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00255
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