A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli

Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-l...

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Vydáno v:J Med Chem
Hlavní autoři: Goldberg, Joel A., Nguyen, Ha, Kumar, Vijay, Spencer, Elizabeth J., Hoyer, Denton, Marshall, Emma K., Cmolik, Anna, O’Shea, Margaret, Marshall, Steven H., Hujer, Andrea M., Hujer, Kristine M., Rudin, Susan D., Domitrovic, T. Nicholas, Bethel, Christopher R., Papp-Wallace, Krisztina M., Logan, Latania K., Perez, Federico, Jacobs, Michael R., van Duin, David, Kreiswirth, Barry M., Bonomo, Robert A., Plummer, Mark S., van den Akker, Focco
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7590959/
https://ncbi.nlm.nih.gov/pubmed/32420736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00255
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