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Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases

Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. The hydrogen bonding network in their active site plays an important conformational role and supports the phosphatase activity. Nearly half of dual-specificit...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lai, Chih-Hsuan, Chang, Co-Chih, Chuang, Huai-Chia, Tan, Tse-Hua, Lyu, Ping-Chiang
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589817/
https://ncbi.nlm.nih.gov/pubmed/33053837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207515
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