Resveratrol Rescue Indoxyl Sulfate-Induced Deterioration of Osteoblastogenesis via the Aryl Hydrocarbon Receptor /MAPK Pathway

Indoxyl sulfate (IS), a uremic toxin derived from dietary tryptophan metabolism by the gut microbiota, is an endogenous aryl hydrocarbon receptor (AhR) agonist and a key player in bone remodeling. Resveratrol (RSV), an AhR antagonist, plays a protective role in shielding against AhR ligands. Our stu...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Liu, Wen-Chih, Shyu, Jia-Fwu, Lin, Yuh-Feng, Chiu, Hui-Wen, Lim, Paik Seong, Lu, Chien-Lin, Zheng, Cai-Mei, Hou, Yi-Chou, Chen, Po-Han, Lu, Kuo-Cheng
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589702/
https://ncbi.nlm.nih.gov/pubmed/33050571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207483
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