Dissecting Cellular Mechanisms of Long-Chain Acylcarnitines-Driven Cardiotoxicity: Disturbance of Calcium Homeostasis, Activation of Ca(2+)-Dependent Phospholipases, and Mitochondrial Energetics Collapse

Long-chain acylcarnitines (LCAC) are implicated in ischemia-reperfusion (I/R)-induced myocardial injury and mitochondrial dysfunction. Yet, molecular mechanisms underlying involvement of LCAC in cardiac injury are not sufficiently studied. It is known that in cardiomyocytes, palmitoylcarnitine (PC)...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Berezhnov, Alexey V., Fedotova, Evgeniya I., Nenov, Miroslav N., Kasymov, Vitaly A., Pimenov, Oleg Yu., Dynnik, Vladimir V.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589681/
https://ncbi.nlm.nih.gov/pubmed/33050414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207461
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