Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein (TXNIP)

Overnutrition contributes to insulin resistance, obesity and metabolic stress, initiating a loss of functional beta-cells and diabetes development. Whether these damaging effects are amplified in advanced age is barely investigated. Therefore, New Zealand Obese (NZO) mice, a well-established model f...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Kehm, Richard, Jähnert, Markus, Deubel, Stefanie, Flore, Tanina, König, Jeannette, Jung, Tobias, Stadion, Mandy, Jonas, Wenke, Schürmann, Annette, Grune, Tilman, Höhn, Annika
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589534/
https://ncbi.nlm.nih.gov/pubmed/33128997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101748
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