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Macroautophagy is impaired in old murine brain tissue as well as in senescent human fibroblasts

The overall decrease in proteolytic activity in aging can promote and accelerate protein accumulation and metabolic disturbances. To specifically analyze changes in macroautophagy (MA) we quantified different autophagy-related proteins (ATGs) in young, adult and old murine tissue as well as in young...

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Publicat a:Redox Biol
Autors principals: Ott, Christiane, König, Jeannette, Höhn, Annika, Jung, Tobias, Grune, Tilman
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099282/
https://ncbi.nlm.nih.gov/pubmed/27825071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.015
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