Targeting SKA3 suppresses the proliferation and chemoresistance of laryngeal squamous cell carcinoma via impairing PLK1–AKT axis-mediated glycolysis

Spindle and kinetochore-associated complex subunit 3 (SKA3) is a well-known regulator of chromosome separation and cell division, which plays an important role in cell proliferation. However, the mechanism of SKA3 regulating tumor proliferation via reprogramming metabolism is unknown. Here, SKA3 is...

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Udgivet i:Cell Death Dis
Main Authors: Gao, Wei, Zhang, Yuliang, Luo, Hongjie, Niu, Min, Zheng, Xiwang, Hu, Wanglai, Cui, Jiajia, Xue, Xuting, Bo, Yunfeng, Dai, Fengsheng, Lu, Yan, Yang, Dongli, Guo, Yujia, Guo, Huina, Li, Huizheng, Zhang, Yu, Yang, Tao, Li, Li, Zhang, Linshi, Hou, Rui, Wen, Shuxin, An, Changming, Ma, Teng, Jin, Lei, Xu, Wei, Wu, Yongyan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589524/
https://ncbi.nlm.nih.gov/pubmed/33106477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03104-6
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