De Novo T790M Mutation in an L858R Epidermal Growth Factor Receptor Mutant-Associated Lung Adenocarcinoma

SIMPLE SUMMARY: Lung adenocarcinomas caused by (L858R) somatic mutation in the epidermal growth factor receptor (EGFR) show good therapeutic response to tyrosine kinase inhibitors. These tumors develop resistance to therapy mainly after acquired T790M mutation. However, whether the T790M mutation oc...

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Published in:Cancers (Basel)
Main Authors: Fujiwara, Takumi, Kobayashi, Tetsu, Yasuma, Taro, D’Alessandro-Gabazza, Corina N., Toda, Masaaki, Fujimoto, Hajime, Fujiwara, Kentaro, Takeshita, Atsuro, Nishihama, Kota, Okano, Tomohito, D’Alessandro, Valeria Fridman, Takei, Yoshiyuki, Hataji, Osamu, Gabazza, Esteban C
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589092/
https://ncbi.nlm.nih.gov/pubmed/33096790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12103074
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