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Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epileptic network oscillations

BACKGROUND AND PURPOSE: Perampanel is a newly approved anticonvulsant uniquely targeting AMPA receptors, which mediate the most abundant form of excitatory synaptic transmission in the brain. However, the network mechanism underlying the anti‐epileptic effect of the AMPAergic inhibition remains to b...

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Publicat a:Br J Pharmacol
Autors principals: Yang, Ya‐Chin, Wang, Guan‐Hsun, Chuang, Ai‐Yu, Hsueh, Shu‐Wei
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589018/
https://ncbi.nlm.nih.gov/pubmed/32901915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15253
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