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Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epileptic network oscillations
BACKGROUND AND PURPOSE: Perampanel is a newly approved anticonvulsant uniquely targeting AMPA receptors, which mediate the most abundant form of excitatory synaptic transmission in the brain. However, the network mechanism underlying the anti‐epileptic effect of the AMPAergic inhibition remains to b...
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| Pubblicato in: | Br J Pharmacol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7589018/ https://ncbi.nlm.nih.gov/pubmed/32901915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15253 |
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