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In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity

AA3266 is a hybrid compound consisting of opioid receptor agonist and neurokinin-1 receptor (NK1R) antagonist pharmacophores. It was designed with the desire to have an analgesic molecule with improved properties and auxiliary anticancer activity. Previously, the compound was found to exhibit high a...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Matalińska, Joanna, Lipiński, Piotr F. J., Kosson, Piotr, Kosińska, Katarzyna, Misicka, Aleksandra
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588979/
https://ncbi.nlm.nih.gov/pubmed/33086743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21207738
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