Affinity of Antifungal Isoxazolo[3,4-b]pyridine-3(1H)-Ones to Phospholipids in Immobilized Artificial Membrane (IAM) Chromatography

Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the lipophilicity of drug candidates is determined usi...

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Bibliographische Detailangaben
Veröffentlicht in:Molecules
Hauptverfasser: Ciura, Krzesimir, Fedorowicz, Joanna, Žuvela, Petar, Lovrić, Mario, Kapica, Hanna, Baranowski, Paweł, Sawicki, Wiesław, Wong, Ming Wah, Sączewski, Jarosław
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
Schlagworte:
Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587931/
https://ncbi.nlm.nih.gov/pubmed/33092252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25204835
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