Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

In malaria-naïve children and adults, Plasmodium falciparum -infected red blood cells ( Pf -iRBCs) trigger fever and other symptoms of systemic inflammation. However, in endemic areas where individuals experience repeated Pf infections over many years, the risk of Pf -iRBC-triggered inflammatory sym...

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Udgivet i:bioRxiv
Main Authors: Guha, Rajan, Mathioudaki, Anna, Doumbo, Safiatou, Doumtabe, Didier, Skinner, Jeff, Arora, Gunjan, Siddiqui, Shafiuddin, Li, Shanping, Kayentao, Kassoum, Ongoiba, Aissata, Zaugg, Judith, Traore, Boubacar, Crompton, Peter D.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587779/
https://ncbi.nlm.nih.gov/pubmed/33106806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.21.346197
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