Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors

Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to the purine-like 7-amino-5-hydroxymethylbenzimidazole nucleoside analogue following an optimized synt...

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Publicado no:Molecules
Main Authors: Zhang, Baole, Pang, Luping, Nautiyal, Manesh, De Graef, Steff, Gadakh, Bharat, Lescrinier, Eveline, Rozenski, Jef, Strelkov, Sergei V., Weeks, Stephen D., Van Aerschot, Arthur
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7587597/
https://ncbi.nlm.nih.gov/pubmed/33081246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25204751
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