CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profiles of C1Q genes were negatively correlated with t...

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Udgivet i:Eur J Immunol
Main Authors: Silva‐Cardoso, Sandra C., Tao, Weiyang, Fernández, Beatriz Malvar, Boes, Marianne, Radstake, Timothy R.D.J., Pandit, Aridaman
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
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Letters to the Editor
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586983/
https://ncbi.nlm.nih.gov/pubmed/32502279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948341
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