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Protein-Protein Cross-Coupling via Palladium-Protein Oxidative Addition Complexes from Cysteine Residues

Few chemical methods exist for the covalent conjugation of two proteins. We report the preparation of site-specific protein-protein conjugates that arise from the sequential cross-coupling of cysteine residues on two different proteins. The method involves the synthesis of stable palladium-protein o...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Dhanjee, Heemal H., Saebi, Azin, Buslov, Ivan, Loftis, Alexander R., Buchwald, Stephen L., Pentelute, Bradley L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586714/
https://ncbi.nlm.nih.gov/pubmed/32364380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03143
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