Design and Rationale for First-in-Human Phase 1 Immunovirotherapy Clinical Trial of Oncolytic HSV G207 to Treat Malignant Pediatric Cerebellar Brain Tumors

Brain tumors represent the most common pediatric solid neoplasms and leading cause of childhood cancer-related morbidity and mortality. Although most adult brain tumors are supratentorial and arise in the cerebrum, the majority of pediatric brain tumors are infratentorial and arise in the posterior...

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Vydáno v:Hum Gene Ther
Hlavní autoři: Bernstock, Joshua D., Bag, Asim K., Fiveash, John, Kachurak, Kara, Elsayed, Galal, Chagoya, Gustavo, Gessler, Florian, Valdes, Pablo A., Madan-Swain, Avi, Whitley, Richard, Markert, James M., Gillespie, G. Yancey, Johnston, James M., Friedman, Gregory K.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2020
Témata:
Protocol—Clinical Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585605/
https://ncbi.nlm.nih.gov/pubmed/32657154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.101
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