Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium damage, somatic electromotility disturbances, and presynaptic ribbon degeneration over time, which led to the gradu...

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Detaylı Bibliyografya
Yayımlandı:Cell Death Dis
Asıl Yazarlar: Zhou, Han, Qian, Xiaoyun, Xu, Nana, Zhang, Shasha, Zhu, Guangjie, Zhang, Yuan, Liu, Dingding, Cheng, Cheng, Zhu, Xiaocheng, Liu, Yongze, Lu, Ling, Tang, Jie, Chai, Renjie, Gao, Xia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585579/
https://ncbi.nlm.nih.gov/pubmed/33099575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03110-8
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