Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice

Atg7 is an indispensable factor that plays a role in canonical nonselective autophagy. Here we show that genetic ablation of Atg7 in outer hair cells (OHCs) in mice caused stereocilium damage, somatic electromotility disturbances, and presynaptic ribbon degeneration over time, which led to the gradu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhou, Han, Qian, Xiaoyun, Xu, Nana, Zhang, Shasha, Zhu, Guangjie, Zhang, Yuan, Liu, Dingding, Cheng, Cheng, Zhu, Xiaocheng, Liu, Yongze, Lu, Ling, Tang, Jie, Chai, Renjie, Gao, Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585579/
https://ncbi.nlm.nih.gov/pubmed/33099575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03110-8
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