Development, Characterization, and in-vivo Pharmacokinetic Study of Lamotrigine Solid Self-Nanoemulsifying Drug Delivery System

PURPOSE: This study aimed to prepare solid self-nanoemulsified drug delivery system (S-SNEDDS) of lamotrigine (LMG) for enhancing its dissolution and oral bioavailability (BA). METHODS: Nineteen liquid SNEDDS were prepared (R1-R19) using D-optimal design with different ratios of oil, surfactant (S),...

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Detalles Bibliográficos
Publicado en:Drug Des Devel Ther
Main Authors: Abdelmonem, Rehab, Azer, Marian Sobhy, Makky, Amna, Zaghloul, Abdelazim, El-Nabarawi, Mohamed, Nada, Aly
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2020
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7585523/
https://ncbi.nlm.nih.gov/pubmed/33116420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S263898
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