Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells

To better understand host-virus genetic dependencies and find potential therapeutic targets for COVID-19, we performed a genome-scale CRISPR loss-of-function screen to identify host factors required for SARS-CoV-2 viral infection of human alveolar epithelial cells. Top-ranked genes cluster into dist...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cell
Asıl Yazarlar: Daniloski, Zharko, Jordan, Tristan X., Wessels, Hans-Hermann, Hoagland, Daisy A., Kasela, Silva, Legut, Mateusz, Maniatis, Silas, Mimitou, Eleni P., Lu, Lu, Geller, Evan, Danziger, Oded, Rosenberg, Brad R., Phatnani, Hemali, Smibert, Peter, Lappalainen, Tuuli, tenOever, Benjamin R., Sanjana, Neville E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Inc. 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584921/
https://ncbi.nlm.nih.gov/pubmed/33147445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.10.030
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