Estrogen receptor β regulates AKT activity through up-regulation of INPP4B and inhibits migration of prostate cancer cell line PC-3

Loss of the tumor suppressor, PTEN, is one of the most common findings in prostate cancer (PCa). This loss leads to overactive Akt signaling, which is correlated with increased metastasis and androgen independence. However, another tumor suppressor, inositol-polyphosphate 4-phosphatase type II (INPP...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Chaurasiya, Surendra, Wu, Wanfu, Strom, Anders M., Warner, Margaret, Gustafsson, Jan-Åke
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584887/
https://ncbi.nlm.nih.gov/pubmed/33020300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007160117
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